May produce arteriolar dilation. Metolazone; Examples of loop diuretics include: Bumetanide (Bumex) Ethacrynic acid (Edecrin) Furosemide (Lasix) Torsemide (Soaanz) Examples of potassium-sparing diuretics include: Amiloride (Midamor) Eplerenone (Inspra) Spironolactone (Aldactone, Carospir) Triamterene (Dyrenium) Metolazone has the molecular formula C 16 H 16 ClN 3 O 3 S, the chemical name 7-chloro-1, 2, 3, 4-tetrahydro-2-methyl-3- (2-methylphenyl)-4-oxo-6-quinazolinesulfonamide, and a molecular weight of 365.83. . K+-sparing drugs are spironolactone, triamterene, and amiloride. Hypokalaemia can occur with thiazides and related diuretics. Metolazone - Clinical Pharmacology The actions of Metolazone result from interference with the renal tubular mechanism of electrolyte reabsorption. Metolazone causes a greater degree of potassium depletion than thiazides [4]. The steroidal aldosterone antagonists can also be used for treatment of primary hyperaldosteronism. Potassium-Sparing Diuretics - YouTube Due to a large number of drugs in the T diuretics class, and the possible difference . However, no evidence suggests that timing of metolazone dose has any effect. The increased delivery of sodium to the distal tubular exchange site results in increased potassium excretion. metolazone: thiazide-like in action, not structure : polythiazide : Loop: bumetanide . Its paruhadalah sekitar empat belas jam, mirip dengan indapamide tapi jauh lebih lama dari hydrochlorothiazide. 2. Diuretic Agents - The Cardiology Advisor They inhibit the competitive binding of aldosterone to . Thiazide diuretics include: Chlorothiazide (Diuril) Hydrochlorothiazide (Aquazide, Esidrix, Ezide, Hydrocot, HydroDIURIL, Microzide, Oretic) Indapamide (Lozol) Methyclothiazide (Aquatensen, Enduron) Metolazone (Mykrox, Zaroxolyn) Chlorthalidone (Thalitone) Bendroflumethiazide (Naturetin) Thiazide diuretics and potassium-sparing diuretics may . [34] reported a reverse-phase high-performance liquid chromatographic . Which Is A Potassium-sparing Diuretic Used In The Treatment Of Heart ... Metolazone has the molecular formula C H ClN S, the chemical name 7-chloro-1, 2, 3, 4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide, and a molecular weight of 365.83. . Following are the aldosterone antagonists currently . Diuretic Therapy in Heart Failure - Current Approaches Metolazone - Wikipedia (See . Contributors RxWiki Editorial Team When potassium-sparing diuretics are administered with other diuretics such as furosemide, potassium loss is decreased, which may be beneficial. They are typically used as an adjunct in management of hypertension, cirrhosis, and congestive heart failure. CV Pharmacology | Diuretics The most potent diuretics are the loop diuretics, followed by mannitol, metolazone (a thiazide-like diuretic), the thiazides, and the potassium-sparing diuretics The potency of diuretics is a function of where they work in the nephron to inhibit sodium and water resorption.
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